Isolation of Adult Hippocampal Neural Stem Cells

2025

Martín-Suárez S.Methods Mol Biol. 2025;2899:21-34. doi: 10.1007/978-1-0716-4386-0_2. PMID: 40067614
Purinergic receptor antagonism reduces interictal discharges and rescues cognitive function in a mouse model of temporal lobe epilepsy 
Espinosa N, Martín-Suárez S, Lara-Vasquez A, Montero T, Muro-García T, Fernandez G, Encinas-Pérez JM, Fuentealba P. Front Neurosci. 2025 Apr 4;19:1513135. doi: 10.3389/fnins.2025.1513135. PMID: 40255857; PMCID: PMC12007451.

2024

Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice 
Bielefeld P*, Martirosyan A*, Martín-Suárez S*, Apresyan A, Meerhoff GF, Pestana F, Poovathingal S, Reijner N, Koning W, Clement RA, Van der Veen I, Toledo EM, Polzer O, Durá I, Hovhannisyan S, Nilges BS, Bogdoll A, Kashikar ND, Lucassen PJ, Belgard TG, Encinas JM, Holt MG, Fitzsimons CP. Nat Commun. 2024 Jun 18;15(1):5222. doi: 10.1038/s41467-024-49299-6. PMID: 38890340; PMCID: PMC11189490.
Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2 
Pastor-Alonso O, Syeda Zahra A, Kaske B, García-Moreno F, Tetzlaff F, Bockelmann E, Grunwald V, Martín-Suárez S, Riecken K, Witte OW, Encinas JM, Urbach A. EMBO J. 2024 Feb;43(3):317-338. doi: 10.1038/s44318-023-00011-2. Epub 2023 Dec 20. PMID: 38177500; PMCID: PMC10897295.
HB-EGF activates EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures 
Pastor-Alonso O, Durá I, Bernardo-Castro S, Varea E, Muro-García T, Martín-Suárez S, Encinas-Pérez JM, Pineda JR.Life Sci Alliance. 2024 Jul 8;7(9):e202201840. doi: 10.26508/lsa.202201840. PMID: 38977310; PMCID: PMC11231495.

2023

Blockage of STAT3 during epileptogenesis prevents GABAergic loss and imprinting of the epileptic state 
The differential response to neuronal hyperexcitation and neuroinflammation of the hippocampal neurogenic niche 

P.I

Martín-Suárez S, Cortes JM, Bonifazi P. Brain. 2023 Aug 1;146(8):3416-3430. doi: 10.1093/brain/awad055. PMID: 36825472; PMCID: PMC10393395.
Ruiz-Clavijo L, Martín-Suárez S. . Front Neurosci. 2023 Jul 11;17:1186256. doi: 10.3389/fnins.2023.1186256. PMID: 37496737; PMCID: PMC10366379.

2019-2022

The future belongs to those who prepare for it today 
Martín-Suárez S, Encinas JM. The future belongs to those who prepare for it today. Cell Stem Cell. 2021 May 6;28(5):783-785. doi: 10.1016/j.stem.2021.04.014. PMID: 33961757.

2021

Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments 
Satta V, Alonso C, Díez P, Martín-Suárez S, Rubio M, Encinas JM, Fernández-Ruiz J, Sagredo O. Front Mol Neurosci. 2021 Jan 29;13:602801. doi: 10.3389/fnmol.2020.602801. PMID: 33584198; PMCID: PMC7879984.

2020

Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain 
Schouten M, Bielefeld P, Garcia-Corzo L, Passchier EMJ, Gradari S, Jungenitz T, Pons-Espinal M, Gebara E, Martín-Suárez S, Lucassen PJ, De Vries HE, Trejo JL, Schwarzacher SW, De Pietri Tonelli D, Toni N, Mira H, Encinas JM, Fitzsimons CP. Mol Psychiatry. 2020 Jul;25(7):1382-1405. doi: 10.1038/s41380-019-0440-2. Epub 2019 Jun 20. PMID: 31222184; PMCID: PMC7303016.
Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome
Martín-Suárez S, Abiega O, Ricobaraza A, Hernandez-Alcoceba R, Encinas JM. AFront Cell Dev Biol. 2020 Jul 21;8:654. doi: 10.3389/fcell.2020.00654. PMID: 32793597; PMCID: PMC7385077.
Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division
Valcárcel-Martín R*, Martín-Suárez S*, Muro-García T, Pastor-Alonso O, Rodríguez de Fonseca F, Estivill-Torrús G, Encinas JM.Front Neurosci. 2020 Aug 14;14:811. doi: 10.3389/fnins.2020.00811.doi: 10.3389/fnins.2020.614857. PMID: 32922255; PMCID: PMC7456947.

2019

Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus

Martín-Suárez S, Valero J, Muro-García T, Encinas JM. Aging Cell. 2019 Aug;18(4):e12958. doi: 10.1111/acel.12958. Epub 2019 Apr 15. PMID: 30989815; PMCID: PMC6612636.
Reactive Disruption of the Hippocampal Neurogenic Niche After Induction of Seizures by Injection of Kainic Acid in the Amygdala 
Muro-García T*, Martín-Suárez S*, Espinosa N, Valcárcel-Martín R, Marinas A, Zaldumbide L, Galbarriatu L, Sierra A, Fuentealba P, Encinas JM. ReactiveFront Cell Dev Biol. 2019 Aug 20;7:158. doi: 10.3389/fcell.2019.00158. PMID: 31482091; PMCID: PMC6710991.

2019-2022

The future belongs to those who prepare for it today 
Martín-Suárez S, Encinas JM. The future belongs to those who prepare for it today. Cell Stem Cell. 2021 May 6;28(5):783-785. doi: 10.1016/j.stem.2021.04.014. PMID: 33961757.

2021

Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments 
Satta V, Alonso C, Díez P, Martín-Suárez S, Rubio M, Encinas JM, Fernández-Ruiz J, Sagredo O. Front Mol Neurosci. 2021 Jan 29;13:602801. doi: 10.3389/fnmol.2020.602801. PMID: 33584198; PMCID: PMC7879984.

2020

Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain 
Schouten M, Bielefeld P, Garcia-Corzo L, Passchier EMJ, Gradari S, Jungenitz T, Pons-Espinal M, Gebara E, Martín-Suárez S, Lucassen PJ, De Vries HE, Trejo JL, Schwarzacher SW, De Pietri Tonelli D, Toni N, Mira H, Encinas JM, Fitzsimons CP. Mol Psychiatry. 2020 Jul;25(7):1382-1405. doi: 10.1038/s41380-019-0440-2. Epub 2019 Jun 20. PMID: 31222184; PMCID: PMC7303016.
Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome
Martín-Suárez S, Abiega O, Ricobaraza A, Hernandez-Alcoceba R, Encinas JM. AFront Cell Dev Biol. 2020 Jul 21;8:654. doi: 10.3389/fcell.2020.00654. PMID: 32793597; PMCID: PMC7385077.
Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division
Valcárcel-Martín R*, Martín-Suárez S*, Muro-García T, Pastor-Alonso O, Rodríguez de Fonseca F, Estivill-Torrús G, Encinas JM.Front Neurosci. 2020 Aug 14;14:811. doi: 10.3389/fnins.2020.00811.doi: 10.3389/fnins.2020.614857. PMID: 32922255; PMCID: PMC7456947.

2019

Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus

Martín-Suárez S, Valero J, Muro-García T, Encinas JM. Aging Cell. 2019 Aug;18(4):e12958. doi: 10.1111/acel.12958. Epub 2019 Apr 15. PMID: 30989815; PMCID: PMC6612636.
Reactive Disruption of the Hippocampal Neurogenic Niche After Induction of Seizures by Injection of Kainic Acid in the Amygdala 
Muro-García T*, Martín-Suárez S*, Espinosa N, Valcárcel-Martín R, Marinas A, Zaldumbide L, Galbarriatu L, Sierra A, Fuentealba P, Encinas JM. ReactiveFront Cell Dev Biol. 2019 Aug 20;7:158. doi: 10.3389/fcell.2019.00158. PMID: 31482091; PMCID: PMC6710991.

2012-2018

2015

2013

Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis 
Sierra A, Martín-Suárez S, Valcárcel-Martín R, Pascual-Brazo J, Aelvoet SA, Abiega O, Deudero JJ, Brewster AL, Bernales I, Anderson AE, Baekelandt V, Maletić-Savatić M, Encinas JM. Cell Stem Cell. 2015 May 7;16(5):488-503. doi: 10.1016/j.stem.2015.04.003. PMID: 25957904; PMCID: PMC4443499.
A developmental perspective on adult hippocampal neurogenesis 
Encinas JM, Sierra A, Valcárcel-Martín R, Martín-Suárez S. Int J Dev Neurosci. 2013 Nov;31(7):640-5. doi: 10.1016/j.ijdevneu.2013.04.001. Epub 2013 Apr 12. PMID: 23588197.
ADDRESS
UPV/EHU Science Park, Sede building 3rd Leioa Bizkaia 48940 ESGoogle Maps
(+34) 94 601 8138
soraya.martin@achucarro.org
Our Hours
Monday - Friday 09:00 AM - 17:00 PM
Laboratory of Neurogenesis, Neuroinflammation and Network Dynamics (3ND)
Achucarro Basque Center for Neuroscience