Targeting Neuroinflammation to Preserve Neuronal Network Activity in Epilepsy
Growing evidence highlights neuroinflammation as a critical target in epilepsy treatment.
Epilepsy is associated with profound alterations in neuronal network dynamics driven by neuroinflammatory processes. Targeting neuroinflammation offers a strategy to preserve functional circuit architecture without suppressing overall brain activity.
We investigate how early metabolic changes in neural stem cells initiate a switch toward a pro-neuroinflammatory reactive state during pathological neuronal hyperexcitation. Using multi-omics, functional imaging, and in vivo circuit analysis, the project dissects how altered stem cell metabolism is inherited by newborn neurons and reshapes hippocampal networks. By targeting these early metabolic events, StemFire aims to preserve stem cell identity, prevent aberrant neurogenesis, and protect neuronal circuit function in disorders such as epilepsy and traumatic brain injury.
Early metabolic reprogramming links NSCs reactivity to neuroinflammation and circuit dysfunction.
Targeting Neuroinflammation to Preserve Neuronal Network Activity in Epilepsy
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